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It is difficult to know exactly when the shift from gelatine to agar occurred. As often happens for scientific breakthroughs, agar was likely adopted incrementally alongside the use of other growth media. In 1913, for example, the first diagnosis of Serratia marcescens as a human pathogen was made by growing it on agar as well as on potatoes.，详情可参考新收录的资料
My colleagues have extolled the virtues of various coffee-making methods over the past few days, and I can't fault them for having elaborate rituals around caffeination. I, too, appreciate the slow-and-steady movements of a French press or the delightful bubbling of a percolator. But they are not for me—not on a weekday, given how much of a menace I can be in the mornings. Since I was a little girl, I have woken up on the wrong side of the bed more often than not, with bedhead that matches my attitude problem. There's no time for boiling water in an aesthetically pleasing gooseneck kettle. There's no patience for a sweet little moment with my fancy burr grinder and my portafilter. From the moment I open my eyes, it's a race to caffeinate my brain as quickly as possible.
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These requirements will hopefully become more clear as we start trying out different algorithms, and seeing examples of their successes and failure modes. Before we get too deep in the weeds, though, I want to emphasise that not all reactive systems are the same, and some don’t need all of these requirements. For example, lots of simple reactive systems work just fine with static dependencies only, trading off some efficiency wins for implementation simplicity. Similarly, glitches are only important if they are actually observed, so some reactive systems will be glitch-y by default, but provide tools for syncing nodes together if the user actually needs them to be in sync.，这一点在新收录的资料中也有详细论述